Cell-based Publications:


Functionally enhanced human stem cell derived hepatocytes in galactosylated cellulosic sponges for hepatotoxicity testing

Tasnim F, Toh YC, Qu Y, Li H, Phan D, Narmada BC, Ananthanarayanan A, Mittal N, Meng RQ, Yu H.

Mol Pharm. 2016 May 24. Published on: 2016 | View Link


Scalable spheroid model of human hepatocytes for hepatitis C infection and replication

Ananthanarayanan A, Nugraha B, Triyatni M, Hart S, Sankuratri S, Yu H.

Mol Pharm. 2014 Jul 7;11(7):2106-14. doi: 10.1021/mp500063y. Published on: 2014 | View Link


Tethered spheroids as an in vitro hepatocyte model for drug safety screening

Xia L, Sakban RB, Qu Y, Hong X, Zhang W, Nugraha B, Tong WH, Ananthanarayanan A, Zheng B, Chau IY, Jia R, McMillian M, Silva J, Dallas S, Yu H.

Biomaterials. 2012 Mar;33(7):2165-76. doi: 10.1016/j.biomaterials.2011.12.006. Published on: 2012 | View Link


Purpose-driven biomaterials research in liver-tissue engineering

Ananthanarayanan A, Narmada BC, Mo X, McMillian M, Yu H.

Trends Biotechnol. 2011 Mar;29(3):110-8. doi: 10.1016/j.tibtech.2010.10.006. Published on: 2011 | View Link


A robust high-throughput sandwich cell-based drug screening platform

Zhang S, Tong W, Zheng B, Susanto TA, Xia L, Zhang C, Ananthanarayanan A, Tuo X, Sakban RB, Jia R, Iliescu C, Chai KH, McMillian M, Shen S, Leo H, Yu H.

Biomaterials. 2011 Feb;32(4):1229-41. doi: 10.1016/j.biomaterials.2010.09.064. Published on: 2011 | View Link


Constrained spheroids for prolonged hepatocyte culture

Tong WH, Fang Y, Yan J, Hong X, Hari Singh N, Wang SR, Nugraha B, Xia L, Fong EL, Iliescu C, Yu H.

Biomaterials. 2016 Feb;80:106-20. doi: 10.1016/j.biomaterials.2015.11.036. Published on: 2016 | View Link


Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model

Xia L, Hong X, Sakban RB, Qu Y, Singh NH, McMillian M, Dallas S, Silva J, Sensenhauser C, Zhao S, Lim HK, Yu H.

J Appl Toxicol. 2016 Feb;36(2):320-9. doi: 10.1002/jat.3189. Published on: 2016 | View Link


HepaRG culture in tethered spheroids as an in vitro three-dimensional model for drug safety screening

Wang Z, Luo X, Anene-Nzelu C, Yu Y, Hong X, Singh NH, Xia L, Liu S, Yu H.

J Appl Toxicol. 2015 Aug;35(8):909-17. doi: 10.1002/jat.3090. Published on: 2015 | View Link


Release of (and lessons learned from mining) a pioneering large toxicogenomics database

Sandhu KS, Veeramachaneni V, Yao X, Nie A, Lord P, Amaratunga D, McMillian MK, Verheyen GR.

Pharmacogenomics. 2015 Jul;16(8):779-801. doi: 10.2217/pgs.15.38. Published on: 2015 | View Link


ABC gene-ranking for prediction of drug-induced cholestasis in rats

Yauheniya Cherkasa, Michael K. McMillianb,1, Dhammika Amaratungab,2,Nandini Raghavanc, Jennifer C. Sasaki

Toxicology Reports 3. 2016 Jan:252-261. doi:10.1016/j.toxrep.2016.01.009. Published on: 2016 | View Link


Society of Toxicology Meeting 2016 Posters:


Hepatocyte Spheroid Cultures in Galactosylated Cellulosic Sponge for Drug DMPK and Efficacy Testing

A. Ananthanarayanan, Yinghua Qu, Nisha Hari Singh, Bramasta Nugraha, Michael McMillian, Hanry Yu

Published on: 2016 | View Link


Evaluating Reactive Acyl Glucuronides Formation from Diclofenac using a Resazurin/ Resorufin Assay with Primary Rat Hepatocytes

N. Hari Singh, M. McMillian, Y. Qu, C. W. Ng, Y. Zhou, H. Yu and A. Ananthanarayanan

Published on: 2016 | View Link


Image-based Publications:


qFibrosis: a fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients

Xu S, Wang Y, Tai DC, Wang S, Cheng CL, Peng Q, Yan J, Chen Y, Sun J, Liang X, Zhu Y, Rajapakse JC, Welsch RE, So PT, Wee A, Hou J, Yu H.

J Hepatol. 2014 Aug;61(2):260-9. doi: 10.1016/j.jhep.2014.02.015. Published on: 2014 | View Link


Quantification of liver fibrosis via second harmonic imaging of the Glisson’s capsule from liver surface

Xu S, Kang CH, Gou X, Peng Q, Yan J, Zhuo S, Cheng CL, He Y, Kang Y, Xia W, So PT, Welsch R, Rajapakse JC, Yu H.

J Biophotonics. 2016 Apr;9(4):351-63. doi: 10.1002/jbio.201500001. Published on: 2016 | View Link


Experimenting liver fibrosis diagnostic by two photon excitation microscopy and Bag-of-Features image classification

Stanciu SG, Xu S, Peng Q, Yan J, Stanciu GA, Welsch RE, So PT, Csucs G, Yu H.

Sci Rep. 2014 Apr 10;4:4636. doi: 10.1038/srep04636. Published on: 2014 | View Link


Correlation of MR elastography with morphometric quantification of liver fibrosis (Fibro-C-Index) in chronic hepatitis B

Venkatesh SK, Xu S, Tai D, Yu H, Wee A.

Magn Reson Med. 2014 Oct;72(4):1123-9. doi: 10.1002/mrm.25002. Published on: 2014 | View Link



Spatiotemporal quantification of cell dynamics in the lung following influenza virus infection

Yin L, Xu S, Cheng J, Zheng D, Limmon GV, Leung NH, Rajapakse JC, Chow VT, Chen J, Yu H.

J Biomed Opt. 2013 Apr;18(4):046001. doi: 10.1117/1.JBO.18.4.046001. Published on: 2013 | View Link


Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia

Yin L, Zheng D, Limmon GV, Leung NH, Xu S, Rajapakse JC, Yu H, Chow VT, Chen J.

Respir Res. 2014 Sep 30;15:116. doi: 10.1186/s12931-014-0116-z. Published on: 2014 | View Link



Differential remodeling of extracellular matrices by breast cancer initiating cells

Raja AM, Xu S, Zhuo S, Tai DC, Sun W, So PT, Welsch RE, Chen CS, Yu H.

J Biophotonics. 2015 Oct;8(10):804-15. doi: 10.1002/jbio.201400079 Published on: 2015 | View Link


Second harmonic generation microscopy is a novel technique for differential diagnosis of breast fibroepithelial lesions

Tan WJ, Yan J, Xu S, Thike AA, Bay BH, Yu H, Tan MH, Tan PH.

J Clin Pathol. 2015 Dec;68(12):1033-5. doi: 10.1136/jclinpath-2015-203231. Published on: 2015 | View Link



A method for human teratogen detection by geometrically confined cell differentiation and migration

Xing J, Toh YC, Xu S, Yu H.

Sci Rep. 2015 Aug 3;5:12387. doi: 10.1038/srep12387. Published on: 2015 | View Link